Understanding Functional Connectivity of Sensory and Motor Pathways to Specific Regions of the Lower Urinary Tract.

Correlation of Electrical Impedance and Evoked Potentials With Properties of the Electrode Interface Using in Situ Block-Face Imaging of the Rat Pelvic Nerve

SC Payne, C Bowman, JR Keast, EP Trang, PB Osborne, JB Fallon

2025-12-01

Background Electrical stimulation is an emerging therapy for urologic disorders. The interface between electrode and neural tissue..

A 3D Atlas of Visceral and Somatic Pelvic Motor Neurons in Whole Mounts of Female and Male Rat Spinal Cords

JP Fuller-Jackson, Z Yang, NM Wiedmann, A Watson, NEC Jenkins, JR Keast, PB Osborne

2025-11-01

The sexually dimorphic genitourinary organs and specialized striated muscles in the pelvis are controlled by a spinal cord motor n..

An adeno-associated viral labeling approach to visualize the meso- and microanatomy of mechanosensory afferents and autonomic innervation of the rat urinary bladder

NM Wiedmann, JP Fuller-Jackson, PB Osborne, JR Keast

2024-01-01

The urinary bladder is supplied by a rich network of sensory and autonomic axons, commonly visualized by immunolabeling for neural..

Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array

Sophie C Payne, Peregrine B Osborne, Alex Thompson, Calvin D Eiber, Janet R Keast, James B Fallon

2023-12-01

Real-time closed-loop control of neuromodulation devices requires long-term monitoring of neural activity in the peripheral nervou..

A novel statistical methodology for quantifying the spatial arrangements of axons in peripheral nerves

AS Shemonti, E Plebani, NP Biscola, DM Jaffey, LA Havton, JR Keast, A Pothen, MM Dundar, TL Powley, B Rajwa

2023-01-01

A thorough understanding of the neuroanatomy of peripheral nerves is required for a better insight into their function and the dev..

Editorial: Multiscale anatomy and biophysics of the autonomic nervous system: implications for neuromodulation

NA Pelot, M Vaseghi, L Reznikov, PB Osborne, SV Conde

2023-01-01

High-throughput segmentation of unmyelinated axons by deep learning

E Plebani, NP Biscola, LA Havton, B Rajwa, AS Shemonti, D Jaffey, T Powley, JR Keast, KH Lu, MM Dundar

2022-12-01

Axonal characterizations of connectomes in healthy and disease phenotypes are surprisingly incomplete and biased because unmyelina..

Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems

X Chen, S Ravindra Kumar, CD Adams, D Yang, T Wang, DA Wolfe, CM Arokiaraj, V Ngo, LJ Campos, JA Griffiths, T Ichiki, SK Mazmanian, PB Osborne, JR Keast, CT Miller, AS Fox, IM Chiu, V Gradinaru

2022-07-20

Gene therapy offers great promise in addressing neuropathologies associated with the central and peripheral nervous systems (CNS a..

Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces

CD Eiber, SC Payne, NP Biscola, LA Havton, JR Keast, PB Osborne, JB Fallon

2021-12-01

Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective ..

Regional targeting of bladder and urethra afferents in the lumbosacral spinal cord of male and female rats: A multiscale analysis

JP Fuller-Jackson, PB Osborne, JR Keast

2021-11-01

Sensorimotor circuits of the lumbosacral spinal cord are required for lower urinary tract (LUT) regulation as well as being engage..

Sex differences in c-Fos and EGR-1/Zif268 activity maps of rat sacral spinal cord following cystometry-induced micturition

NM Wiedmann, AW Wong, JR Keast, PB Osborne

2021-02-01

Storage and voiding of urine from the lower urinary tract (LUT) must be timed precisely to occur in appropriate behavioral context..

Preliminary Minimum Reporting Requirements for In-Vivo Neural Interface Research: I. Implantable Neural Interfaces

Calvin Eiber, Jean Delbeke, Jorge Cardoso, Martijn de Neeling, Sam John, Chang Won Lee, Jerry Skefos, Argus Sun, Dimiter Prodanov, Zach McKinney

2021-01-01

The pace of research and development in neuroscience, neurotechnology, and neurorehabilitation is rapidly accelerating, with the n..

Recording of Electrically Evoked Neural Activity and Bladder Pressure Responses in Awake Rats Chronically Implanted With a Pelvic Nerve Array

SC Payne, NM Wiedmann, CD Eiber, AW Wong, P Senn, PB Osborne, JR Keast, JB Fallon

2020-12-17

Bioelectronic medical devices are well established and widely used in the treatment of urological dysfunction. Approved targets in..

Functional segregation within the pelvic nerve of male rats: a meso- and microscopic analysis

MM Bertrand, N Korajkic, PB Osborne, JR Keast

2020-10-01

The pelvic splanchnic nerves are essential for pelvic organ function and have been proposed as targets for neuromodulation. We hav..

SPARC: A Multiscale Analysis of the Structure of the Rat Lower Urinary Tract (LUT) and Connectivity of Sensory and Autonomic Nerve Terminals

Janet Keast, Nicole Wiedmann, Alan Watson, Nathaniel Jenkins, Dane Gerneke, Peter Hunter, Peregrine Osborne

2020-04-01

<jats:sec> <jats:label/> <jats:p>Storage and voiding of urine are normally precisely contr..

SPARC: Building a Three-Dimensional Atlas of Spinal Cord Circuits Regulating Lower Urinary Tract Function

John-Paul Fuller-Jackson, Agnes Wong, Alan Watson, Nathaniel Jenkins, Janet Keast, Peregrine Osborne

2020-04-01

<jats:sec> <jats:label/> <jats:p>Lumbar and sacral spinal cord circuits are critical for p..

SPARC: Minimally Invasive Recording of Neural Activity During Natural Voiding in Anaesthetized Rats

Sophie Payne, Peregrine Osborne, Janet Keast, James Fallon

2020-04-01

<jats:sec> <jats:title>Background</jats:title> <jats:p>Controlling urination with bioelect..

SPARC: Modelling a Bidirectional Bioelectric Pelvic Nerve Interface

Calvin Eiber, Martin Bertrand, Janet Keast, Peregrine Osborne

2020-04-01

<jats:sec> <jats:title>Background</jats:title> <jats:p>Micturition (urination) and contine..

Dissection of pelvic autonomic ganglia and associated nerves in male and female rats

MM Bertrand, JR Keast

2020-03-01

The bilateral major pelvic ganglia (MPG; synonym, pelvic ganglia) are the primary source of postganglionic sympathetic and parasym..

Simulating bidirectional peripheral neural interfaces in EIDORS

Calvin D Eiber, Janet R Keast, Peregrine B Osborne

2020-01-01

Bioelectronic neural interfaces that deliver adaptive therapeutic stimulation in an intelligent manner must be able to sense and s..

Autonomic nervous system and male reproduction

JR Keast, PB Osborne

2018-01-01

The autonomic nervous system regulates the smooth muscle activity, glandular secretions and blood flow in the male reproductive or..

Stimulating bioelectronic medicine discovery for urological disorders

PB Osborne

2017-11-29